Boutique-hotel connoisseurs Mr & Mrs Smith love a jaw-dropping vista, especially when it's from the comfy confines of a stunning suite. Cabins perched above the craggy cliffs of Big Sur, California; luxe tents in front of Australia's most famous natural wonder, the red rock Uluru; the best spot for a 360-degree sweep of Rome -- voyeurs, get ready: From these retreats you can see everything.

Skyscrapers, flashes of neon, and spectacular sunsets over the Hudson River are on offer out of every window of this Manhattan monolith. It's a gloriously glassy high-rise lording over the Meatpacking District, with witty minimalist interiors, sexy bathrooms, and two almost-impossible-to-get-into nightclubs. You'll have a better shot at Le Bain, which has an indoor hot tub that has seen some things, as well as a huge roofdeck with some the city's best panoramas.
Room to book: The views get better the higher you go; shoot for the eighth floor and above. Standard Suites are far and away the most glam, with three walls of glass and a freestanding bathtub positioned in one corner.

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Hotels with their sights set right on volcanoes aren't easy to come by, and that's exactly why this coral-pink hacienda was a shoo-in for this list. Built more than 120 years ago, its elegant arched buildings sit serenely in a lush landscape of coffee plants and avenues of bamboo with the awe-inspiring Colima volcano in the distance.
Room to book: For a straight shot at the smoke-haloed peak, you can't beat the El Quetzal Junior Suite, which has a lovely little terrace.

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Built by a billionaire with a taste for isolation, this all-white ranch is surrounded by 4,000 acres of plains, where cattle graze on yellow-green fields and flocks of wild doves disappear into the sunset. (Trust us, you can gaze for days.) It's not all endless grasslands, though -- hop on one of the provided bikes and peddle your way to the beach just over a mile away. The interiors are equally impressive -- marvel at the huge quartz-fossil wall art in the sitting room and a towering marble statue by noted local sculptor Pablo Atchugarry.
Room to book: Master Suite VIK is a bold, masculine room with wood-paneled walls and an enormous corner terrace. Its feminine counterpart, Master Suite Seveso, has floor-length coral curtains, lime-washed beams, rafters, and floorboards, and wonderful views of the plains.

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This intimate Wine Country retreat is surrounded by sun-soaked vineyards. The best way to enjoy the landscapes is in the late afternoon, relaxing on your private terrace while sipping a glass of fine wine from the hotel's extensive cellar. Indulgent three-course breakfasts, open-air showers, and alfresco massages will set you up perfectly for days of discovering the region's amazing wineries.
Room to book: All accommodations possess balconies, fireplaces, and soaking tubs, but the grand top-floor suite offers the best snapshot of the golden California countryside.

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From the roof terrace of this elegant townhouse, you can play one helluva game of I Spy: In one sweeping glance you've got the Villa Medici, the Spanish Steps, and the Vittoriano, with the domes of St. Peter's and the Vatican in the distance. Most charming are the tiny rooftop gardens the citizens of Rome have cultivated amid the spires and pinnacles. The hotel is an offshoot of the Ferragamo fashion empire, so interiors have been done up with all the shoe-related artwork and photos you'd expect from the designer's star-studded heyday.
Room to book: Deluxe Studio 53 wins easily here, with a marble bathroom sized for a king (and queen) and a balcony that's ideal for scenic breakfasts.

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Strung along the West's most epic cliffs, these design-forward cabins and cottages -- all rich wood and patina-covered metal -- offer a bird's-eye view of the ocean. No, seriously, before they were built, the architect took to the treetops, climbing up to locate the best lookouts. Once you've arrived, the only reason to venture out from your peaks-and-Pacific isolation will be for some divine dining at the Sierra Mar restaurant or to be worked over in the spa.
Room to book: Toward the edge of the property, "Pfeiffer" practically feels like a cocoon, it's so secluded. "Ross," with a triple veranda, is another stellar choice.

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At this glamping (that would be "glamorous camping") destination you can admire the country's most striking natural landmark -- Uluru, or Ayer's Rock -- without lifting your head from the pillow. Sure, you'll be sleeping in a tented cabin, surrounded by the rugged wilderness of the Simpson Desert, but roughing it isn't on the menu -- fine dining and sinfully good spa treatments are.
Room to book: Set at either end of the resort, rooms 1 and 15 (a.k.a. "Sir Sidney Kidman" and "Jane Webb") are the most private, while 6, 7, and 8 ("John Flynn," "Ernest Giles," and "William Christie Gosse") have the most uninterrupted vistas of Uluru.

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A beguiling blend of East meets West, this intimate tropical hideaway has one of the most magical views of, well, pretty much anywhere: In the foreground an infinity pool reflects swaying palms, and in the distance, a temple with a golden stupa tops a faraway hill. Accommodations -- breezy, terraced, and finished in glossy rosewood -- are ultra-luxe.

Room to book: Numbers 501 through 504 have the best vantage points of the frothy green beyond.

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Overlooking Mawgan Porth beach on a windswept patch of Cornwall, this eco-friendly sanctuary takes advantage of its clifftop location with more floor-to-ceiling windows than you can count. And though the hotel shines at bringing the outdoors in (every room comes with its own balcony, terrace, or garden), it also excels at bringing the indoors out (wood-fired hot tubs line the edge of the bay).
Room to book: Even the standard-category "Just Right" rooms offer unobstructed Atlantic visions. But if you want a private garden too, upgrade to a "Unique" room.

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For more insider tips and to book your next trip, contact the travel experts at Mr & Mrs Smith (800-464-2040, mrandmrssmith.com).